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Simultaneous Enantioseparation of Cis-Diltiazem Hydrochloride and Its Metabolite Cis-Desacetyldiltiazem Using High-Performance Liquid Chromatography and Capillary Electrophoresis

Bezhan Chankvetadze, Irma Kartozia, Gottfried Blaschke

J Pharm Biomed Anal. 2002 Jan 1;27(1-2):161-6.

PMID: 11682222

Abstract:

Two alternative methods were developed using high-performance liquid chromatography (HPLC) and capillary electrophoresis (CE) for a simultaneous enantioselective determination of Ca(2+) blocking chiral drug cis-diltiazem hydrochloride (DLT) and its degradation product and metabolite cis-desacetyldiltiazem (Desac-DLT). The methods were compared from the viewpoint of analytical performance. The identification of HPLC peaks were performed using off-line electrospray ionization mass spectrometry. In addition, CE method was evaluated for quantitative determination of minor enantiomeric impurities in pharmacologically active (+)-cis-DLT.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP33286225-A (+)-cis-Diltiazem hydrochloride (+)-cis-Diltiazem hydrochloride 33286-22-5 Price
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