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Simultaneous GLC Analysis of Salicylamide, Phenylpropanolamine Hydrochloride, Caffeine, Chlorpheniramine Maleate, Phenylephrine Hydrochloride, and Pyrilamine Maleate in Capsule Preparations

F De Fabrizio

J Pharm Sci. 1980 Jul;69(7):854-5.

PMID: 7391955

Abstract:

A GLC method is described for the quantitative determination of salicylamide, phenylpropanolamine hydrochloride, caffeine, chlorpheniramine maleate, phenylephrine hydrochloride, and pyrilamine maleate. The sample was dissolved in ethanol, and an aliquot of the solution was brought to dryness and treated with 0.1 ml of 4-(dimethyl-amino)pyridine in pyridine-acetic anhydride (1:1). The components were isolated and measured by applying 1 microliter of the reaction mixture to a chromatograph equipped with a flame-ionization detector and fitted with 8% OV-101 glass columns. The accuracy was good. Dicyclohexylphthalate was used as the internal standard.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP59336-A Pyrilamine maleate Pyrilamine maleate 59-33-6 Price
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