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Simultaneous HPLC Analysis of Pseudophedrine Hydrochloride, Codeine Phosphate, and Triprolidine Hydrochloride in Liquid Dosage Forms

Simultaneous HPLC Analysis of Pseudophedrine Hydrochloride, Codeine Phosphate, and Triprolidine Hydrochloride in Liquid Dosage Forms

Adnan Manassra, Mustafa Khamis, Magdy El-Dakiky, Zuhair Abdel-Qader, Fuad Al-Rimawi

J Pharm Biomed Anal. 2010 Mar 11;51(4):991-3.

PMID: 19954915

Abstract:

An HPLC method using UV detection is proposed for the simultaneous determination of pseudophedrine hydrochloride, codeine phosphate, and triprolidine hydrochloride in liquid formulation. C18 column (250mmx4.0mm) is used as the stationary phase with a mixture of methanol:acetate buffer:acetonitrile (85:5:10, v/v) as the mobile phase. The factors affecting column separation of the analytes were studied. The calibration graphs exhibited a linear concentration range of 0.06-1.0mg/ml for pseudophedrine hydrochloride, 0.02-1.0mg/ml for codeine phosphate, and 0.0025-1.0mg/ml for triprolidine hydrochloride for a sample size of 5microl with correlation coefficients of better than 0.999 for all active ingredients studied. The results demonstrate that this method is reliable, reproducible and suitable for routine use with analysis time of less than 4min.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP6138790	Triprolidine hydrochloride		6138-79-0	Price

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