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Simultaneous Quantification of Methiocarb and Its Metabolites, Methiocarb Sulfoxide and Methiocarb Sulfone, in Five Food Products of Animal Origin Using Tandem Mass Spectrometry

Simultaneous Quantification of Methiocarb and Its Metabolites, Methiocarb Sulfoxide and Methiocarb Sulfone, in Five Food Products of Animal Origin Using Tandem Mass Spectrometry

Md Musfiqur Rahman, A M Abd El-Aty, Tae-Woong Na, Joon-Seong Park, Md Humayun Kabir, Hyung Suk Chung, Han Sol Lee, Ho-Chul Shin, Jae-Han Shim

J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Aug 15;1060:387-394.

PMID: 28666230

Abstract:

A simultaneous analytical method was developed for the determination of methiocarb and its metabolites, methiocarb sulfoxide and methiocarb sulfone, in five livestock products (chicken, pork, beef, table egg, and milk) using liquid chromatography-tandem mass spectrometry. Due to the rapid degradation of methiocarb and its metabolites, a quick sample preparation method was developed using acetonitrile and salts followed by purification via dispersive- solid phase extraction (d-SPE). Seven-point calibration curves were constructed separately in each matrix, and good linearity was observed in each matrix-matched calibration curve with a coefficient of determination (R2) ≥ 0.991. The limits of detection and quantification were 0.0016 and 0.005mg/kg, respectively, for all tested analytes in various matrices. The method was validated in triplicate at three fortification levels (equivalent to 1, 2, and 10 times the limit of quantification) with a recovery rate ranging between 76.4-118.0% and a relative standard deviation≤10.0%. The developed method was successfully applied to market samples, and no residues of methiocarb and/or its metabolites were observed in the tested samples. In sum, this method can be applied for the routine analysis of methiocarb and its metabolites in foods of animal origins.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP2635101	Methiocarb sulfoxide		2635-10-1	Price

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