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Simultaneous RP-HPLC Estimation of Trifluoperazine Hydrochloride and Chlordiazepoxide in Tablet Dosage Forms

Sejal K Patel, N J Patel

Indian J Pharm Sci. 2009 Sep;71(5):545-7.

PMID: 20502574

Abstract:

A binary mixture of trifluoperazine HCl and chlordiazepoxide was determined using reversed-phase liquid chromatography method using methanol:water (97:03, v/v) pumped at a flow rate of 1.0 ml/min. Quantification was achieved with ultraviolet detection at 262 nm over concentration ranges of 0.1-1 and 0.5-5 mug/ml; mean accuracies were 101.05+/-0.47 and 98.97+/-0.33 %, respectively. The method was successively applied to tablet dosage forms as no chromatographic interferences from the tablet excipients were observed. The method retained its accuracy and precision when the standard addition technique was applied.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP440175-B Trifluoperazine hydrochloride Trifluoperazine hydrochloride 440-17-5 Price
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