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Simultaneous Voltammetric Detection of 5-hydroxyindole-3-acetic Acid and 5-hydroxytryptamine Using a Glassy Carbon Electrode Modified With Conducting Polymer and Platinised Carbon Nanofibers

Simultaneous Voltammetric Detection of 5-hydroxyindole-3-acetic Acid and 5-hydroxytryptamine Using a Glassy Carbon Electrode Modified With Conducting Polymer and Platinised Carbon Nanofibers

Zina Fredj, MounirBen Ali, Baljit Singh, Eithne Dempsey

Mikrochim Acta. 2018 Aug 13;185(9):412.

PMID: 30105543

Abstract:

The authors describe a method for simultaneous voltammetric determination of 5-hydroxytryptamine (serotonin; 5-HT) and its metabolite 5-hydroxyindoleacetic acid (5-HIAA). A glassy carbon electrode was modified with poly(pyrrole-3-carboxylic acid) and with platinised carbon nanofibers to obtain a sensor that can quantify 5-HT and 5-HIAA with detection limits of 10 nM and 20 nM, respectively. The peak currents, best measured at voltages of 170 mV and 500 mV (vs. Ag/AgCl) for 5-HT and 5-HIAA, increase linearly in the 0.01-100 μM concentration range for both analytes. The method was successfully applied to the quantitation of 5-HT and 5-HIAA in spiked artificial urine samples, and the sensor can be used up to 10 days. Graphical abstract A new electroanalytical device was developed for separation and quantitation of 5-hydroxytryptamine (5-HT) and 5-hydroxyindole-3-acetic acid (5-HIAA), based on stripping square wave voltammetry, exploiting conducting polymer surfaces on platinised carbon nanofiber supports.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP871125712	4-Propoxy-2,3,5,6-tetrafluorophenylboronic acid		871125-71-2	Price

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