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Single-isomer Sulfated Alpha-Cyclodextrins for Capillary Electrophoresis. Part 2. Hexakis(6-O-sulfo)-alpha-cyclodextrin: Synthesis, Analytical Characterization, and Initial Screening Tests

Single-isomer Sulfated Alpha-Cyclodextrins for Capillary Electrophoresis. Part 2. Hexakis(6-O-sulfo)-alpha-cyclodextrin: Synthesis, Analytical Characterization, and Initial Screening Tests

Shulan Li, Gyula Vigh

Electrophoresis. 2004 May;25(9):1201-10.

PMID: 15174039

Abstract:

The second member of the family of single-isomer sulfated alpha-cyclodextrins, the sodium salt of hexakis(6-O-sulfo)-alpha-cyclodextrin (HxS), has been synthesized, analytically characterized, and used as the resolving agent for the capillary electrophoretic separation of the enantiomers of nonionic, weak-acid and weak-base analytes present in our initial screening kit. HxS interacted less strongly with many of the analytes tested than the larger-ring analogs, heptakis(6-O-sulfo)-beta-cyclodextrin (HS) and octakis(6-O-sulfo)-gamma-cyclodextrin (OS). For some of the analytes, the separation selectivities obtained with HxS were complementary to those observed with hexakis(2,3-di-O-acetyl-6-O-sulfo)-alpha-cyclodextrin (HxDAS), HS, and OS. For all analytes, the effective mobilities and separation selectivities as a function of the background electrolyte concentration of HxS followed the trends that were found for HxDAS, HS, and OS.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
LS741344	Hexakis (6-O-tertbutyl-dimethylsilyl)-α-cyclodextrin			Price

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