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SIS3, a Specific Inhibitor of smad3, Attenuates Bleomycin-Induced Pulmonary Fibrosis in Mice

SIS3, a Specific Inhibitor of smad3, Attenuates Bleomycin-Induced Pulmonary Fibrosis in Mice

Juanjuan Shou, Jingjing Cao, Shanshan Zhang, Ruicong Sun, Mengmeng Zhao, Keqiang Chen, Shao Bo Su, Jianhua Yang, Tianshu Yang

Biochem Biophys Res Commun. 2018 Sep 5;503(2):757-762.

PMID: 29913150

Abstract:

Pulmonary fibrosis (PF) is a fatal respiratory disease with no effective medical treatments available. TGF-β/Smads signaling has been implicated to play an essential in the pathogenesis of PF, in which Smad3 act as the integrator of pro-fibrosis signals. In this study, we determined the effect of SIS3, a specific inhibitor of Smad3, in an experimental mouse model of lung fibrosis. We observed that SIS3 treatment significantly reduced bleomycin (BLM)-induced pathological changes and collagen deposition in the lung as indicated by Masson staining, real-time PCR and hydroxyproline content assay. As expected, the levels of Smad3 phosphorylation were decreased in the lung of mice treated with SIS3. Furthermore, SIS3 treatment also suppressed BLM-induced infiltration of inflammatory cells in the lung. Taken together, our results suggest that SIS3 ameliorated BLM-induced PF in mouse lungs. Thus, targeting Smad3 with SIS3 may be an effective approach for treatment of fibrotic disorders.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP521984485	SIS3		521984-48-5	Price

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