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Six Month Inhalation Studies of Pirbuterol Acetate Aerosol in the Beagle Dog and Squirrel Monkey

Six Month Inhalation Studies of Pirbuterol Acetate Aerosol in the Beagle Dog and Squirrel Monkey

H V Levinsky, C Breckenridge, R Lough, D A Gonci, H M McIlhenny, S Qureshi

Fundam Appl Toxicol. Nov-Dec 1981;1(6):426-31.

PMID: 7185594

Abstract:

Groups of Beagle dogs and Squirrel monkeys were exposed to aerosols of pirbuterol acetate, a new bronchodilator at doses of 0, 200, 400 and 800 micrograms of pirbuterol/kg body weight daily for 6 months. Each group consisted of 4 dogs or 6 monkeys per sex. Dogs were exposed by face mask and monkeys were exposed by head only in a manifold. Plasma drug concentrations indicated that expected levels of drug exposure were achieved in both species. No significant alterations were revealed in physical appearance and body weights, hematological and blood biochemical analyses, urinalyses, ophthalmoscopy, assessment of cardiovascular status, pulmonary function or gross and histopathology. Examination of the respiratory tract showed no morphological changes that could be attributed to pirbuterol acetate inhalation.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP65652440-A	Pirbuterol acetate		65652-44-0	Price

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