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Small-molecule Inducer of β Cell Proliferation Identified by High-Throughput Screening

Small-molecule Inducer of β Cell Proliferation Identified by High-Throughput Screening

Weijun Shen, Matthew S Tremblay, Vishal A Deshmukh, Weidong Wang, Christophe M Filippi, George Harb, You-qing Zhang, Anwesh Kamireddy, Janine E Baaten, Qihui Jin, Tom Wu, Jonathan G Swoboda, Charles Y Cho, etc.

J Am Chem Soc. 2013 Feb 6;135(5):1669-72.

PMID: 23330637

Abstract:

The identification of factors that promote β cell proliferation could ultimately move type 1 diabetes treatment away from insulin injection therapy and toward a cure. We have performed high-throughput, cell-based screens using rodent β cell lines to identify molecules that induce proliferation of β cells. Herein we report the discovery and characterization of WS6, a novel small molecule that promotes β cell proliferation in rodent and human primary islets. In the RIP-DTA mouse model of β cell ablation, WS6 normalized blood glucose and induced concomitant increases in β cell proliferation and β cell number. Affinity pulldown and kinase profiling studies implicate Erb3 binding protein-1 and the IκB kinase pathway in the mechanism of action of WS6.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP1421227533	WS6		1421227-53-3	Price

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