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Small-molecule Inducers of Insulin Expression in Pancreatic Alpha-Cells

Dina Fomina-Yadlin, Stefan Kubicek, Deepika Walpita, Vlado Dancik, Jacob Hecksher-Sørensen, Joshua A Bittker, Tanaz Sharifnia, Alykhan Shamji, Paul A Clemons, Bridget K Wagner, Stuart L Schreiber

Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):15099-104.

PMID: 20696901

Abstract:

High-content screening for small-molecule inducers of insulin expression identified the compound BRD7389, which caused alpha-cells to adopt several morphological and gene expression features of a beta-cell state. Assay-performance profile analysis suggests kinase inhibition as a mechanism of action, and we show that biochemical and cellular inhibition of the RSK kinase family by BRD7389 is likely related to its ability induce a beta-cell-like state. BRD7389 also increases the endocrine cell content and function of donor human pancreatic islets in culture.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP376382115 BRD7389 BRD7389 376382-11-5 Price
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