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Small Size Mesoporous Organosilica Nanorods With Different Aspect Ratios: Synthesis and Cellular Uptake

Small Size Mesoporous Organosilica Nanorods With Different Aspect Ratios: Synthesis and Cellular Uptake

Yanjiao Li, Wenwen Guo, Xiaodan Su, Lin Ou-Yang, Meng Dang, Jun Tao, Guangming Lu, Zhaogang Teng

J Colloid Interface Sci. 2018 Feb 15;512:134-140.

PMID: 29055795

Abstract:

In the work, small size thioether-bridged mesoporous organosilica nanorod (MONRs) are successfully synthesized using cetyltrimethylammonium bromide (CTAB) as structure-directing agent and bis[3-(triethoxysilyl)propyl]tetrasulfide (TETS) and tetraethoxysilane (TEOS) as co-precursors. The MONRs have tunable aspect ratios of 2, 3, and 4 (denoted as MONRs-2, MONRs-3, and MONRs-4), small and controllable lengths (75-310nm), high surface area (570-870cm2g-1), uniform mesopores (2.4-2.6nm), large pore volume (0.34cm3g-1), and excellent biocompatibility. The uptake of the MONRs by multidrug resistant human breast cancer MDR-MCF-7 cells is related to their aspect ratios. The MONRs-3 shows a faster and higher cellular internalization compared to the MONRs-4 and MONRs-2, respectively. Thanks to the high cellular uptake, doxorubicin (DOX) loaded MONRs-3 show obviously improved chemotherapeutic effect on MDR-MCF-7 cancer cells. It is expected that the MONRs provide a useful platform for drug delivery and therapeutics.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP40372723	Bis[3-(triethoxysilyl)propyl] tetrasulfide		40372-72-3	Price

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