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Smooth Muscle-Depressant Activity of AP-18, a Putative TRPA1 Antagonist in the Guinea Pig Intestine

Lorand Bartho, Zsolt Sándor, Dezsö Kelemen, Robert Papp, Rita Benko

Pharmacology. 2014;94(3-4):131-4.

PMID: 25247599

Abstract:

AP-18, a putative antagonist at TRPA1 receptor/ion channel, caused smooth muscle relaxation at 10-100 µmol/l. It inhibited cholinergic twitch responses evoked by electrical field stimulation of cholinergic nerves as well as contractions in response to acetylcholine and histamine in the guinea pig small intestine. AP-18 (30 µmol/l) blocked spontaneous contractions of longitudinal strips of human jejunum. It is concluded that AP-18 may have limited value in studying TRPA1-mediated responses in smooth muscles and should probably be used with care in other preparations because of possible nonspecific effects.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP55224947 AP-18 AP-18 55224-94-7 Price
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