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Sodium Butyrate Prevents Radiation-Induced Cognitive Impairment by Restoring pCREB/BDNF Expression

Hae June Lee, Yeonghoon Son, Minyoung Lee, Changjong Moon, Sung Ho Kim, In Sik Shin, Miyoung Yang, Sangwoo Bae, Joong Sun Kim

Neural Regen Res. 2019 Sep;14(9):1530-1535.

PMID: 31089051

Abstract:

Sodium butyrate is a histone deacetylase inhibitor that affects various types of brain damages. To investigate the effects of sodium butyrate on hippocampal dysfunction that occurs after whole-brain irradiation in animal models and the effect of sodium butyrate on radiation exposure-induced cognitive impairments, adult C57BL/6 mice were intraperitoneally treated with 0.6 g/kg sodium butyrate before exposure to 10 Gy cranial irradiation. Cognitive impairment in adult C57BL/6 mice was evaluated via an object recognition test 30 days after irradiation. We also detected the expression levels of neurogenic cell markers (doublecortin) and phosphorylated cAMP response element binding protein/brain-derived neurotrophic factor. Radiation-exposed mice had decreased cognitive function and hippocampal doublecortin and phosphorylated cAMP response element binding protein/brain-derived neurotrophic factor expression. Sodium butyrate pretreatment reversed these changes. These findings suggest that sodium butyrate can improve radiation-induced cognitive dysfunction through inhibiting the decrease in hippocampal phosphorylated cAMP response element binding protein/brain-derived neurotrophic factor expression. The study procedures were approved by the Institutional Animal Care and Use Committee of Korea Institute of Radiological Medical Sciences (approval No. KIRAMS16-0002) on December 30, 2016.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP156547-A Sodium butyrate Sodium butyrate 156-54-7 Price
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