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Sodium Citrate Inhibits the Proliferation of Human Gastric Adenocarcinoma Epithelia Cells

Sodium Citrate Inhibits the Proliferation of Human Gastric Adenocarcinoma Epithelia Cells

Yuan Xia, Xulong Zhang, Agula Bo, Juan Sun, Minhui Li

Oncol Lett. 2018 May;15(5):6622-6628.

PMID: 29616124

Abstract:

The objective of the present study was to investigate the cytotoxic effects of sodium citrate on human gastric adenocarcinoma epithelia AGS cells. Numerous cytotoxicity-associated sodium citrate-induced effects were assessed, including cell viability and proliferation, cytokine expression and caspase activity. In vitro studies demonstrated that incubation with sodium citrate (>3.125 mM) inhibited AGS cell viability and proliferation in a dose-dependent manner. Incubation with sodium citrate for 24 h revealed that the levels of interleukin-1β (IL-1β), IL-8 and tumor necrosis factor increased with an increasing of dose of sodium citrate, whereas the IL-6 levels exhibited only a slight alteration. In addition, increases in caspase-3 and -9 activities were associated with increased duration of treatment and dosage of sodium citrate. Collectively, the results of the present study demonstrated that treatment with sodium citrate at higher concentrations or for longer durations exerts a cytotoxic effect on AGS cells via the induction of the intrinsic apoptosis pathway and the alteration in the levels of certain cytokines.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP6132043	Sodium citrate		6132-04-3	Price

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