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Sodium tetrachloroaurate(III) Dihydrate-Catalyzed Efficient Synthesis of 1,5-benzodiazepine and Quinoxaline Derivatives

Ren-xin Shi, Yun-kui Liu, Zhen-yuan Xu

J Zhejiang Univ Sci B. 2010 Feb;11(2):102-8.

PMID: 20104644

Abstract:

Both 1,5-benzodiazepine and quinoxaline derivatives are important heterocycles in pharmaceuticals. We describe an efficient and clean method for the synthesis of 1,5-benzodiazepines from o-phenylenediamine and ketones catalyzed by sodium tetrachloroaurate(III) dihydrate under mild conditions. The catalyst was shown to be equally effective for the synthesis of quinoxalines from o-phenylenediamine and alpha-bromo ketones under the similar reaction conditions. This method produced good yields.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP13874027 Sodium tetrachloroaurate(III) dihydrate Sodium tetrachloroaurate(III) dihydrate 13874-02-7 Price
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