0

Solasodine Reverses Stemness and Epithelial-Mesenchymal Transition in Human Colorectal Cancer

Yu-Wen Zhuang, Cun-En Wu, Jin-Yong Zhou, Zhi-Ming Zhao, Chun-Li Liu, Jun-Yi Shen, Hui Cai, Shen-Lin Liu

Biochem Biophys Res Commun. 2018 Oct 28;505(2):485-491.

PMID: 30268504

Abstract:

Adverse side effects of conventional chemotherapy, acquired resistance and fatal tumor metastasis of human colorectal cancer (CRC) are propelling the exploration for novel selective anticarcinogens. Solasodine is a main active component isolated from Solanum incanum L that exhibited a potent stemness and invasion inhibitory effect on human colorectal cancer HCT116 cells. Colony Spheroid formation assay showed that solasodine dose-dependently prohibited HCT116 cell stemness. CD133, CD44, Nanog, Oct-4 and Sox-2 were inhibited by solasodine to reverse stemness and similar mechanism was stimulated in vivo. Transwell and scratch wound assays revealed that solasodine impeded HCT116 cell invasion and migration potential strengthened by TGF-β1. Moreover, solasodine attenuated TGF-β1-induced EMT and decreased MMPs while in vivo study showed the same trend. The results of this study implied that solasodine may be a novel therapeutic drug for CRC treatment.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP126170-A Solasodine Solasodine 126-17-0 Price
qrcode