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Solid-State Characterization and Biological Activity of Betulonic Acid Derivatives

Ionuţ Ledeţi, Ştefana Avram, Vasile Bercean, Gabriela Vlase, Titus Vlase, Adriana Ledeţi, Istvan Zupko, Marius Mioc, Lenuţa-Maria Şuta, Codruţa Şoica, Cristina Dehelean

Molecules. 2015 Dec 18;20(12):22691-702.

PMID: 26694347

Abstract:

Betulonic acid belongs to the pentacyclic triterpenic derivative class and can be obtained through the selective oxidation of betulin. In this study we set obtaining several functionalized derivatives of this compound by its condensation with several amino compounds such as aminoguanidine, hydroxylamine, n-butylamine and thiosemicarbazide as our goal. The functionalization of the parent compound led to several molecules with antiproliferative potential, the most promising being 3-2-carbamothioylhydrazonolup-20(29)-en-28-oic acid.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP4481623 Betulonic acid Betulonic acid 4481-62-3 Price
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