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Solid-state Fluorescence of the Trihydrate Phases of Ampicillin and Amoxicillin

Solid-state Fluorescence of the Trihydrate Phases of Ampicillin and Amoxicillin

Harry G Brittain

AAPS PharmSciTech. 2005 Oct 22;6(3):E444-8.

PMID: 16354003

Abstract:

The purpose of this work was to study the effects of crystal structure on the solid-state photoluminescence of the trihydrate phases of ampicillin and amoxicillin, and to contrast these spectra with analogous spectra obtained on the molecules dissolved in a solution phase. The polymorphic identity of the analytes was established using x-ray powder diffraction and Fourier transform infrared absorption spectroscopy, and the solid-state luminescence spectra obtained under ambient conditions. It was found that the solid-state excitation and emission spectra of ampicillin trihydrate and amoxicillin trihydrate were dominated by energy transfer and exciton effects, which were manifested as decreases in the energy of the excitation and emission bands of the solid-state systems relative to those of the free molecule in solution. The photoluminescence data revealed that in spite of the known structural similarity of ampicillin trihydrate and amoxicillin trihydrate, the magnitude of the Davydov splitting, and the degree of band energy shifting differed between the 2 systems. This finding indicates that the small differences in crystal structure existing between the 2 compounds leads to measurable differences in the patterns of energy transfer.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP7177482-A	Ampicillin Trihydrate		7177-48-2	Price

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