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Solid-state NMR as an Effective Method of Polymorphic Analysis: Solid Dosage Forms of Clopidogrel Hydrogensulfate

Solid-state NMR as an Effective Method of Polymorphic Analysis: Solid Dosage Forms of Clopidogrel Hydrogensulfate

Edyta Pindelska, Lukasz Szeleszczuk, Dariusz Maciej Pisklak, Andrzej Mazurek, Waclaw Kolodziejski

J Pharm Sci. 2015 Jan;104(1):106-13.

PMID: 25393324

Abstract:

Clopidogrel hydrogensulfate (HSCL) is an antiplatelet agent, one of top-selling drugs in the world. In this paper, we have described a rapid and convenient method of verification which polymorph of HSCL is present in its final solid dosage form. Our methodology based on solid-state NMR spectroscopy and ab initio gauge-including projector-augmented wave calculations of NMR shielding constants is appropriate for currently available commercial solid dosage forms of HSCL. Furthermore, such structural characterization can assist with the development of new pharmaceutical products containing HSCL and also be useful in the identification of counterfeit drugs.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP135046489	(±) Clopidogrel hydrogensulfate		135046-48-9	Price

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