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Solubility Behavior of Phenolic Compounds in Hexane-Ethyl Acetate, Hexane-Ethyl Myristate, and Hexane-Ethyl Pivalate Cosolvent Systems

E Akaho, K Iga, J Kraal, A Hussain

J Pharm Sci. 1981 Nov;70(11):1225-8.

PMID: 7299668

Abstract:

Interactions of phenolic compounds 4-hexylresorcinol and 3,4-dimethylphenol with esters were studied using hexane-ester cosolvent systems by both phase solubility and partitioning methods. The data obtained by the phase solubility method were variable and could not be analyzed by any mathematical model. The data obtained by the partitioning method, however, strongly suggest that 4-hexylresorcinol forms 1:1 and 1:2 complexes with the esters in hexane, while 3,4-dimethylphenol forms only 1:1 complexes with the same esters.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP124061 Ethyl myristate Ethyl myristate 124-06-1 Price
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