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Soluble Angiotensin-Converting Enzyme 2: A Potential Approach for Coronavirus Infection Therapy?

Soluble Angiotensin-Converting Enzyme 2: A Potential Approach for Coronavirus Infection Therapy?

Daniel Batlle, Jan Wysocki, Karla Satchell

Clin Sci (Lond). 2020 Mar 13;134(5):543-545.

PMID: 32167153

Abstract:

A new coronavirus, referred to as SARS-CoV-2, is responsible for the recent outbreak of severe respiratory disease. This outbreak first detected in Wuhan, China in December 2019, has spread to other regions of China and to 25 other countries as of January, 2020. It has been known since the 2003 SARS epidemic that the receptor critical for SARS-CoV entry into host cells is the angiotensin-converting enzyme 2 (ACE2). The S1 domain of the spike protein of SARS-CoV attaches the virus to its cellular receptor ACE2 on the host cells. We thought that it is timely to explain the connection between the SARS-CoV, SARS-CoV-2, ACE2 and the rationale for soluble ACE2 as a potential therapy.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42418003	Angiotensin Converting Enzyme-2, ACE2			Price

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