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Sonic Hedgehog Signaling Is Blue: Insights From the Patched Mutant Mice

Daniel J Merk, Rosalind A Segal

Trends Neurosci. 2018 Dec;41(12):870-872.

PMID: 30471664

Abstract:

The Hedgehog (Hh) pathway is a highly conserved signaling system regulating a range of developmental processes. A 1997 paper by Goodrich and colleagues provided major contributions to understanding the Hh pathway by mutating the gene encoding the Hh receptor, Patched, and thereby developing a mouse model for a human cancer predisposition syndrome, known as Gorlin syndrome. These studies provided one of the first genetically engineered mouse models for brain tumors.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
IAR4248754 Sonic Hedgehog Peptide from mouse Sonic Hedgehog Peptide from mouse Price
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