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Soyasapogenols Reduce Cellular Triglyceride Levels in 3T3-L1 Mouse Adipocyte Cells by Accelerating Triglyceride Lipolysis

Soyasapogenols Reduce Cellular Triglyceride Levels in 3T3-L1 Mouse Adipocyte Cells by Accelerating Triglyceride Lipolysis

Kazuko Iwamoto, Shuichi Kamo, Yuichi Takada, Ayana Ieda, Takatoshi Yamashita, Toshiro Sato, Nobuhiro Zaima, Tatsuya Moriyama

Biochem Biophys Rep. 2018 Sep 27;16:44-49.

PMID: 30294680

Abstract:

Soyasapogenol is a soyasaponin aglycone, which has been suggested to exert a more potent function than the glycoside form. In this study, the effect of soyasapogenol A and B on cultured adipocyte cell function was investigated using mouse 3T3-L1 adipocyte cells. 3T3-L1 cells were treated with insulin, dexamethasone, and 3-isobutyl-1-methylxanthine for differentiation to adipocytes, and the cells were then cultured in the presence of soyasapogenol A or B (6.25 or 12.5 µM). The media were harvested and refreshed every 2 d. After a 10 d culture, the cells were harvested and the triglyceride content of the cells was determined. The triglyceride content of soyasapogenol B-treated cells was significantly lower than those of vehicle-treated cells. Glycerol and free fatty acid levels in the soyasapogenol-treated cell media were higher than those in vehicle cells. However, there was no difference in the level of adipose triglyceride lipase among soyasapogenol A-, soyasapogenol B-, and vehicle-treated cells. The secreted adiponectin and resistin levels of soyasapogenol-treated cell media were also different compared with those of vehicle-treated cells. Especially, the secreted resistin level in soyasapogenol B-treated cell media was obviously reduced compared with that of vehicle-treated cells. Taken together, these results suggest that soyasapogenol B exerted an anti-obesity and anti-diabetic effect on adipocytes by lowering the cellular triglyceride level by accelerating triglyceride lipolysis with reduced resistin secretion.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP595153	Soyasapogenol B		595-15-3	Price

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