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Spatial and Spectral Imaging of Single Micrometer-Sized Solvent Cast Fluorescent Plasticized Poly(vinyl Chloride) Sensing Particles

Spatial and Spectral Imaging of Single Micrometer-Sized Solvent Cast Fluorescent Plasticized Poly(vinyl Chloride) Sensing Particles

I Tsagkatakis, S Peper, E Bakker

Anal Chem. 2001 Jan 15;73(2):315-20.

PMID: 11199984

Abstract:

Microscale plasticized PVC particles doped with hydrophobic ionophores are prepared by solvent evaporation of aqueous suspensions of sensing cocktails (poly(vinyl chloride), plasticizer, active sensing components, and tetrahydrofuran) and tested as particulate microoptical sensors. The particles contain either only the chromoionophore ETH 2458 as active reagent or the potassium ionophore BME-44, chromoionophore ETH 5294, and lipophilic anionic sites NaTFPB. The former system functions according to an anion-hydrogen ion coextraction mechanism and shows a Hofmeister anion selectivity pattern, while the latter sensor containing additional ionophores represents the more complex, truly selective optical sensors based on ion-exchange equilibria. Single microspheres are simultaneously characterized spatially and spectrally by fluorescence microscopy, coupled to a spectrometer equipped with a CCD detector. The results indicate that these microspheres respond in complete analogy to traditional thin-film-based optodes previously reported in the literature. The introduction of small, spherical ionophore-based sensing particles that operate on the basis of bulk extraction principles holds the promise of significantly expanding the available chemical palette of microsphere-based analytical assays.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
ISM6702	Hydrogen ionophore I - cocktail A			Price

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