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Spectrofluorimetric Determination of Acotiamide Hydrochloride Trihydrate in the Presence of Its Oxidative Degradation Product

Spectrofluorimetric Determination of Acotiamide Hydrochloride Trihydrate in the Presence of Its Oxidative Degradation Product

Khalid A M Attia, Mohammed W I Nassar, Ahmed El-Olemy, Sherif Ramzy

Luminescence. 2018 Jun;33(4):806-811.

PMID: 29637695

Abstract:

Acotiamide hydrochloride trihydrate is a novel gastroprokinetic drug which has been recently approved for the treatment of patients with functional dyspepsia. This study presents the first reported to investigate the fluorimetric behavior of acotiamide hydrochloride trihydrate in the presence of its oxidative degradation product. All variables that affect fluorescence intensity were studied and optimized. The described method involved the measurement of native fluorescence of the drug in ethanol at 404 nm after excitation at 326 nm. Calibration plot was found to be linear over the concentration range 0.1-0.9 μg/ml. The specificity of the method has been tested via selective determination of the studied drug in its synthetic mixtures with its degradation product. The proposed method has been successfully applied to the analysis of the drug in its new pharmaceutical dosage form and the results have been statistically compared with the reported HPLC method showing no significant differences by applying t-test and F-test.

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ALP1173021890	Difloxacin-d3 hydrochloride trihydrate		1173021-89-0 (anhydrous)	Price
AS211203	Sarafloxacin-d8 hydrochloride trihydrate			Price

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