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Spectrophotometric Determination of Anthracycline Anticancer Agents With aluminum(III) and Chromazurol S in a Nonionic Surfactant Micellar Medium

Spectrophotometric Determination of Anthracycline Anticancer Agents With aluminum(III) and Chromazurol S in a Nonionic Surfactant Micellar Medium

Masahiro Nakao, Chikako Yamazaki, Hiroshi Tominaga, Takako Yamaguchi, Yoshikazu Fujita

Anal Sci. 2006 Feb;22(2):313-6.

PMID: 16512429

Abstract:

A simple and highly sensitive spectrophotometric method for the determination of anthracycline anticancer agents, such as Daunorubicin hydrochloride (DAU), was established by using aluminum(III) and Chromazurol S (CAS) in a nonionic surfactant micellar medium. In the case of determination of DAU, the apparent molar absorptivity was 1.3 x 10(5) dm3 mol(-1) cm(-1) at 615 nm. Beer's law was obeyed in the concentration range of 0.028 - 2.82 microg ml(-1) for DAU. Owing to no need for solvent extraction, this method could be applied to assays of DAU and related drugs in pharmaceutical preparations.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP23541506-A	Daunorubicin, Hydrochloride - CAS 23541-50-6		23541-50-6	Price

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