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Spectrophotometric Determination of Dimenhydrinate With Reinecke Salt

Spectrophotometric Determination of Dimenhydrinate With Reinecke Salt

A Kar, G I Aniuha

J Pharm Sci. 1981 Jun;70(6):690-1.

PMID: 7252821

Abstract:

A convenient spectrophotometric method was developed for the determination of dimenhydrinate in bulk drug and dosage forms and in 1:1 combinations with aspirin, acetaminophen, meprobamate, phenylephrine, and tolbutamide. The method consisted of reacting dimenhydrinate with reinecke salt in an acidic medium at 27 +/- 2 degrees. The purple precipitate was filtered and dissolved in acetone, and the maximum color absorption attained in 15 min was measured at 540 nm. Evidence is provided to establish the optimal experimental parameters. The stoichiometric balance of the precipitate was determined. Reasonably ideal adherence of the color absorption pattern to the Beer-Lambert law permitted microdetermination of dimenhydrinate in pure form, commercial formulations, laboratory-made combinations, and recovery experiments with good accuracy and repeatability. No interference was observed with any of the drugs or tablet adjuvants.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP13573165	Reinecke salt		13573-16-5	Price

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