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Sphingolipid biosynthetic pathway is crucial for growth, biofilm formation and membrane integrity of Scedosporium boydii

Sphingolipid biosynthetic pathway is crucial for growth, biofilm formation and membrane integrity of Scedosporium boydii

Rodrigo Rollin-Pinheiro, Victor Pereira Rochetti, Mariana Ingrid Dutra da Silva Xisto, Livia Cristina Liporagi-Lopes, Beatriz Bastos, Antonella Rella, Ashutosh Singh, Sonia Rozental, Maurizio Del Poeta, etc.

Future Med Chem. 2019 Nov;11(22):2905-2917.

PMID: 31713454

Abstract:

Aim: Glycosphingolipids are conserved lipids displaying a variety of functions in fungal cells, such as determination of cell polarity and virulence. They have been considered as potent targets for new antifungal drugs. The present work aimed to test two inhibitors, myriocin and DL-threo-1-Phenyl-2-palmitoylamino-3-morpholino-1-propanol, in Scedosporium boydii, a pathogenic fungus which causes a wide range of disease. Materials & methods: Mass spectrometry, microscopy and cell biology approaches showed that treatment with both inhibitors led to defects in fungal growth and membrane integrity, and caused an increased susceptibility to the current antifungal agents. Conclusion: These data demonstrate the antifungal potential of drugs inhibiting sphingolipid biosynthesis, as well as the usefulness of sphingolipids as promising targets for the development of new therapeutic options.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP149022184	DL-threo-1-Phenyl-2-palmitoylamino-3-morpholino-1-propanol		149022-18-4	Price

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