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Sphingosine-1-phosphate: An Enigmatic Signalling Lipid

Sarah Spiegel, Sheldon Milstien

Nat Rev Mol Cell Biol. 2003 May;4(5):397-407.

PMID: 12728273

Abstract:

The evolutionarily conserved actions of the sphingolipid metabolite, sphingosine-1-phosphate (S1P), in yeast, plants and mammals have shown that it has important functions. In higher eukaryotes, S1P is the ligand for a family of five G-protein-coupled receptors. These S1P receptors are differentially expressed, coupled to various G proteins, and regulate angiogenesis, vascular maturation, cardiac development and immunity, and are important for directed cell movement.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP26993306 Sphingosine 1-phosphate Sphingosine 1-phosphate 26993-30-6 Price
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