0

SR 48692 Inhibits Neurotensin-Induced [3H]dopamine Release in Rat Striatal Slices and Mesencephalic Cultures

A Brouard, M Heaulme, R Leyris, D Pelaprat, D Gully, P Kitabgi, G Le Fur, W Rostene

Eur J Pharmacol. 1994 Mar 3;253(3):289-91.

PMID: 8200423

Abstract:

In rat striatal slices, the increase (114 +/- 11%) in K(+)-evoked [3H]dopamine release induced by neurotensin (10 nM) was antagonized by 2-[(1-(7-chloro-4-quinolinyl)-5-(2,6-dimethoxyphenyl)pyrazol-3-yl) carboxylamino]tricyclo(3.3.1.1.3.7)decan-2-carboxylic acid (SR 48692, IC50 = 1.2 +/- 0.11 nM). SR 48692 (100 nM) also suppressed the neurotensin (10 nM)-induced increase (47%) in K(+)-evoked [3H]dopamine release in primary cultures of fetal rat mesencephalic cells. These results further characterize SR 48692 as a potent antagonist of neurotensin receptors in the rat.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP146362701 SR 48692 SR 48692 146362-70-1 Price
qrcode