Home
Resources
Publications
Stability and Compatibility of Anakinra With Intravenous Cimetidine Hydrochloride or Famotidine in 0.9% Sodium Chloride Injection

Stability and Compatibility of Anakinra With Intravenous Cimetidine Hydrochloride or Famotidine in 0.9% Sodium Chloride Injection

M C Nahata, R S Morosco, B K Sabados, T R Weber

J Clin Pharm Ther. 1995 Apr;20(2):97-9.

PMID: 7650081

Abstract:

We designed a study to evaluate the stability and compatibility of anakinra (recombinant human interleukin-1 receptor antagonist) with cimetidine hydrochloride or famotidine in 0.9% sodium chloride injection during a 4-h period at room temperature (22 degrees C) and light. Anakinra was diluted in 0.9% sodium chloride to concentrations of 4 and 36 mg/ml. At each concentration, anakinra was mixed with 3 mg/ml cimetidine or with 1 mg/ml famotidine, in a 50:50 proportion and stored in plastic culture vials with polypropylene caps. The mean concentrations of anakinra, cimetidine hydrochloride, and famotidine exceeded 95% of initial concentrations throughout the study. No changes were noted in the physical appearance, pH, or the chromatograms during the study period. Thus, anakinra appears to be stable and compatible with cimetidine hydrochloride or famotidine when diluted into 0.9% sodium chloride injection for 4 h at ambient room temperature and light.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP70059302-A	Cimetidine hydrochloride		70059-30-2	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: