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Stability of Ceftazidime Pentahydrate Investigated by Thermal Analysis Techniques

Stability of Ceftazidime Pentahydrate Investigated by Thermal Analysis Techniques

Maria Silmara Alves de Santana, Yara Santiago de Oliveira, Jéssica de Castro Fonseca, Wellington Castro Ferreira, Vasco Stascxak Neto, Alejandro Pedro Ayala

J Pharm Sci. 2020 Mar;109(3):1324-1329.

PMID: 31785240

Abstract:

Cephalosporins are among the most frequently used broad-spectrum antimicrobial agents. Ceftazidime is a semisynthetic β-lactam antibiotic for parenteral administration widely used in the clinical practice, which has been categorized as a third-generation cephalosporin antibiotic. This drug crystallizes as a pentahydrate and, as all cephalosporins, it is unstable and subject to hydrolytic degradation. Taking this into account, this study investigates the stability under 2 different conditions (high temperature and exposition to vacuum) by using various techniques, as thermal analysis, Raman spectroscopy, and X-ray powder diffraction supported by multivariate curve resolution. It was proved that ceftazidime pentahydrate is unstable under the studied variables, exhibiting several transformation processes, which were discussed in terms of the crystalline structure.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP78439062-B	Ceftazidime pentahydrate		78439-06-2	Price

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