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Stability of Esmolol Hydrochloride and Sodium Nitroprusside in Intravenous Admixtures

Stability of Esmolol Hydrochloride and Sodium Nitroprusside in Intravenous Admixtures

N N Karnatz, J Wong, D M Baaske, J H Johnson, E R Speicher, D E Herbranson

Am J Hosp Pharm. 1989 Jan;46(1):101-4.

PMID: 2565685

Abstract:

The stability of esmolol hydrochloride and sodium nitroprusside in an admixture containing both drugs was studied. Solutions containing sodium nitroprusside in a final concentration of approximately 200 micrograms/mL and esmolol hydrochloride in a final concentration of 10 mg/mL in 5% dextrose injection were prepared in a 250-mL volumetric flask. The flask was wrapped with a light-protective cover, stored at ambient room temperature (15-30 degrees C), and protected from light. All experiments were conducted in triplicate with samples taken at 0, 2, 4, 8, and 24 hours. Testing included measurement of pH and absorbance at 400 and 600 nm. High-performance liquid chromatography was used to measure esmolol hydrochloride and sodium nitroprusside concentrations. No changes were observed in the physical appearance, pH, or absorbance of the admixtures. Neither the esmolol hydrochloride nor the sodium nitroprusside concentrations varied by more than 4% during the study. Under the conditions studied, esmolol hydrochloride is compatible with sodium nitroprusside in an admixture containing both drugs.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP81161173	Esmolol hydrochloride		81161-17-3	Price

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