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Stability of [(N-morpholine)metylene]daunorubicin Hydrochloride in Solid State

Przemysław Zalewski, Anna Jelińska, Patrycja Prusinowska, Judyta Cielecka-Piontek, Anna Krause, Irena Oszczapowicz

Acta Pol Pharm. Sep-Oct 2011;68(5):759-63.

PMID: 21928722

Abstract:

The influence of temperature and relative air humidity on the stability of the novel derivative of daunorubicin: [(N-morpholine)metylene]daunorubicin hydrochloride was investigated. The process of degradation was studied by using high-performance liquid chromatography with ultraviolet (UV) detection. In dry air, the degradation of [(N-morpholine)metylene]daunorubicin hydrochloride was a first-order reaction depending on the substrate concentration, while at relative air humidity from 60.5 to 90.0% it was an autocatalytic reaction of the first order with respect to MMD concentration. The kinetic and thermodynamic parameters of degradation were calculated.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP23541506-B Daunorubicin hydrochloride Daunorubicin hydrochloride 23541-50-6 Price
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