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Stability of [(N-piperidine)methylene]daunorubicin Hydrochloride and [(N-pyrrolidine)methylene]daunorubicin Hydrochloride in Solid State

Beata Medenecka, Przemysław Zalewski, Witold Kycler, Mikołaj Piekarski, Weronika Lemiech, Irena Oszczapowicz, Anna Jelińska

Acta Pol Pharm. May-Jun 2014;71(3):431-8.

PMID: 25265823

Abstract:

The influence of temperature and relative air humidity on the stability of two novel derivatives of daunorubicin: [(N-piperidine)methylene]daunorubicin hydrochloride and [(N-pyrrolidine)methylene]daunorubicin hydrochloride was investigated. The process of degradation was studied by using high-performance liquid chromatography with ultraviolet (UV) detection. The kinetic and thermodynamic parameters of degradation were calculated.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP23541506-B Daunorubicin hydrochloride Daunorubicin hydrochloride 23541-50-6 Price
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