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Stability Study of Veterinary Drugs in Standard Solutions for LC-MS/MS Screening in Food

Stability Study of Veterinary Drugs in Standard Solutions for LC-MS/MS Screening in Food

Aurélien Desmarchelier, Philipp Feuerrigel, Hassan Fathi Ahmed, Julie Moulin, Andrea Beck, Claudia Mujahid, Thomas Bessaire, Marie-Claude Savoy, Pascal Mottier

Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2018 Apr;35(4):695-705.

PMID: 29377759

Abstract:

A study on stability of veterinary drugs in standard solutions stored at -80°C and at -20°C was conducted over 1 year. Data were acquired on 152 individual stock standard solutions and also on 15 family mixes and 2 working standard solutions. All solutions were prepared, stored and compared 1 year later against freshly prepared ones by LC-MS/MS. A statistical analysis was performed to set the acceptability criteria, taking into account the variability of standard preparations. In individual stock standard solutions stored at -80°C (12 months) and -20°C (9 months), stability was demonstrated for 141 and 140 out of 152 compounds, i.e. for 92% and 93% of compounds, respectively. Drugs were even more stable when solubilised in either diluted family mixes or working standard solutions, with more than 99% and 94% of compounds found unaltered when stored at -80°C and at -20°C, respectively. In mixes, beta-lactams from the cephalosporin (cefadroxil and cephalexin) and penicillin (amoxicillin and ampicillin) families were found to be the least stable compounds when stored at -20°C (6 months), necessitating storage at -80°C to achieve a 1-year shelf life. The study also evidenced solubility issues for two sulfonamides (sulfadiazine and sulfamerazine) in methanol-based solutions. An independent stability study conducted by a second laboratory confirmed the 1-year stability of 3 family mixes-quinolones, sulfonamides and tetracyclines.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP147103944	Cefadroxil Related Compound I		147103-94-4	Price

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