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Stabilization of the c-Myc Protein by CAMKIIγ Promotes T Cell Lymphoma

Stabilization of the c-Myc Protein by CAMKIIγ Promotes T Cell Lymphoma

Ying Gu, Jiawei Zhang, Xiaoxiao Ma, Byung-Wook Kim, Hailong Wang, Jinfan Li, Yi Pan, Yang Xu, Lili Ding, Lu Yang, Chao Guo, Xiwei Wu, Jun Wu, Kirk Wu, Xiaoxian Gan, Gang Li, Ling Li, Stephen J Forman, Wing-Chung Chan, etc.

Cancer Cell. 2017 Jul 10;32(1):115-128.e7.

PMID: 28697340

Abstract:

Although high c-Myc protein expression is observed alongside MYC amplification in some cancers, in most cases protein overexpression occurs in the absence of gene amplification, e.g., T cell lymphoma (TCL). Here, Ca2+/calmodulin-dependent protein kinase II γ (CAMKIIγ) was shown to stabilize the c-Myc protein by directly phosphorylating it at serine 62 (S62). Furthermore, CAMKIIγ was shown to be essential for tumor maintenance. Inhibition of CAMKIIγ with a specific inhibitor destabilized c-Myc and reduced tumor burden. Importantly, high CAMKIIγ levels in patient TCL specimens correlate with increased c-Myc and pS62-c-Myc levels. Together, the CAMKIIγ:c-Myc axis critically influences the development and maintenance of TCL and represents a potential therapeutic target for TCL.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP6078177	Berbamine dihydrochloride		6078-17-7	Price

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