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Staphylococcal Protein A Is a Key Factor in Neutrophil Extracellular Traps Formation

Staphylococcal Protein A Is a Key Factor in Neutrophil Extracellular Traps Formation

Tamara Hoppenbrouwers, Andi R Sultan, Tsion E Abraham, Nicole A Lemmens-den Toom, Silvie Hansenová Maňásková, Wiggert A van Cappellen, Adriaan B Houtsmuller, Willem J B van Wamel, Moniek P M de Maat, Johan W van Neck

Front Immunol. 2018 Feb 5;9:165.

PMID: 29459871

Abstract:

Staphylococcus aureus are strong inducers of neutrophil extracellular traps (NETs), a defense mechanism of neutrophils against pathogens. Our aim was to explore the role of Protein A in S. aureus-induced NETosis. We determined the Protein A production of four different S. aureus strains and found a direct relationship between the degree of NETosis induction and Protein A production: strains producing higher concentrations of Protein A evoke significantly more NETs. A S. aureus strain in which Protein A as well as a second binding protein for immunoglobulins (Sbi) have been knocked-out (ΔSpA ΔSbi) induced significantly less NETosis than the wild-type strain. NETosis induction by this knockout strain can be rescued by the addition of purified Protein A. Dead S. aureus did not induce NETosis. In conclusion, Protein A is a determinant for NETosis induction by S. aureus.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
CS31042971	Protein A			Price

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