Home
Resources
Publications
Starch Film-Coated Microparticles for Oral Colon-Specific Drug Delivery

Starch Film-Coated Microparticles for Oral Colon-Specific Drug Delivery

Jin Chen, Xiaoxi Li, Ling Chen, Fengwei Xie

Carbohydr Polym. 2018 Jul 1;191:242-254.

PMID: 29661315

Abstract:

The aim of this study was to prepare and characterize a novel type of starch-coated microparticles (MPs) allowing site-specific delivery of bioactives to the colon. An oral colon-specific controlled-release system was developed in the form of MPs coated with a resistant starch (RS2/RS3) film (RS@MPs) through an aqueous suspension coating process. The RS2 was chosen from a high-amylose cornstarch with 88.5% digestion resistibility. The RS3 was prepared by a high-temperature/pressure (HTP) treatment, with the following of enzymatic debranching, and retrogradation, resulting in a dramatic increase in enzymatic resistance (RS3 content: 76.6%). RS@MPs showed 40.7% of 5-aminosalicylic acid release within 8 h. The in vivo study of fluorescein-loaded RS@MPs indicated the high acidic and enzymatic resistibility of RS@MPs and a restrained release in the upper GIT. Therefore, RS@MPs has revealed to be a high potential system for accurately targeting bioactive compound delivery to the colon.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP555066	Aminobenzoate sodium		555-06-6	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: