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Stereochemistry of Nucleic Acids and Their Constituents. IX. The Conformation of the Antibiotic Puromycin Dihydrochloride Pentahydrate

Stereochemistry of Nucleic Acids and Their Constituents. IX. The Conformation of the Antibiotic Puromycin Dihydrochloride Pentahydrate

M Sundaralingam, S K Arora

Proc Natl Acad Sci U S A. 1969 Nov;64(3):1021-6.

PMID: 5264134

Abstract:

The elucidation of puromycin structure represents the first case where both a nucleic acid and a protein fragment are found together in a crystal. The molecule displays an elongated conformation with the nucleoside and the p-methoxy-L-phenylalanine in the preferred conformation. The purine and the tyrosine rings form alternating stacks with interplanar spacings of 3.4 A. The inhibitory effect of this antiobiotic may be due, in part, to its unique conformation and the ability of the amide proton on N(3') to hydrogen bond to the active site of the ribosomal enzyme, peptide synthetase.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP58582-A	Puromycin dihydrochloride		58-58-2	Price

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