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Stereoselective Synthesis of 3,7-diarylaminocholestanes by Titanium-Mediated Reductive Amination

Md Wasi Ahmad, Hong-Seok Kim

Steroids. 2014 Oct;88:53-9.

PMID: 25008986

Abstract:

An efficient method for the synthesis of aryl aminocholestanes, using a chlorotriisopropoxytitanium(IV)-mediated reductive amination reaction of 5α-cholestane-3,7-dione, is reported. A series of 3,7-diarylaminocholestane derivatives were prepared according to this methodology in up to 98% yield. These compounds were primarily characterized by (1)H NMR, (13)C NMR, and mass spectrometry.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP20717866 Chlorotriisopropoxytitanium(IV) Chlorotriisopropoxytitanium(IV) 20717-86-6 Price
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