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Stereospecific Ni-catalyzed Cross-Coupling of Potassium Alkenyltrifluoroborates With Alkyl Halides

Gary A Molander, O Andreea Argintaru

Org Lett. 2014 Apr 4;16(7):1904-7.

PMID: 24666316

Abstract:

A general method for the alkenylation of alkyl electrophiles using nearly stoichiometric amounts of the air- and moisture-stable potassium organotrifluoroborates has been developed. Various functional groups were tolerated on both the nucleophilic and electrophilic partner. Reactions of highly substituted E- and Z-alkenyltrifluoroborates, as well as vinyl- and propenyltrifluoroborates, were successful, and no loss of stereochemistry or regiochemistry was observed.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
LS7931480 Potassium propynyltrifluoroborate Potassium propynyltrifluoroborate Price
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