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Stimulation of Rat Cerebellar Guanosine 3',5'-cyclic Monophosphate (Cyclic GMP) Levels: Effects of Amino Acid Antagonists

Stimulation of Rat Cerebellar Guanosine 3',5'-cyclic Monophosphate (Cyclic GMP) Levels: Effects of Amino Acid Antagonists

G A Foster, P J Roberts

Br J Pharmacol. 1981 Nov;74(3):723-9.

PMID: 6117346

Abstract:

1 The ability of glutamate, aspartate and related neuroexcitants to produce large calcium-dependent increases in the levels of guanosine 3',5'-cyclic monophosphate (cyclic GMP) in immature rat cerebellar slices has been demonstrated. 2 These effects were inhibited by selective antagonist compounds, indicating the presence of at least two types of excitatory amino acid receptor mediating the cyclic GMP response. 3 Protoveratrine also produced large increases in cyclic GMP, and this action was antagonized by L-glutamate diethylester suggesting that released endogenous glutamate, subsequently interacting with its postsynaptic receptors, is the predominant mechanism. 4 The kinetic characteristics of several of the inhibitor compounds were investigated.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP7665998	Guanosine 3′,5′-cyclic monophosphate		7665-99-8	Price

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