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Straightforward Access to Biocompatible poly(2-oxazoline)-coated Nanomaterials by Polymerization-Induced Self-Assembly

Dao Le, Friederike Wagner, Masanari Takamiya, I-Lun Hsiao, Gabriela Gil Alvaradejo, Uwe Strähle, Carsten Weiss, Guillaume Delaittre

Chem Commun (Camb). 2019 Mar 26;55(26):3741-3744.

PMID: 30860243

Abstract:

We report the synthesis of poly(2-ethyl-2-oxazoline)-based (PEtOx) nanoobjects by polymerization-induced self-assembly (PISA). First, well-defined PEtOx macromolecular chain transfer agents were synthesized by cationic ring-opening polymerization and click chemistry. The photoinitiated PISA of 2-hydroxypropyl methacrylate mediated by these PEtOx produced nanoobjects spanning the full range of core-shell morphologies. The nanoparticles exhibited high biocompatibility and stealth properties in vitro or in vivo, as well as thermoresponsive behavior.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP25703791 Poly(2-hydroxypropyl methacrylate) Poly(2-hydroxypropyl methacrylate) 25703-79-1 Price
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