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Structural and Molecular Mechanisms for the Control of Eukaryotic 5'-3' mRNA Decay

Structural and Molecular Mechanisms for the Control of Eukaryotic 5'-3' mRNA Decay

Jeffrey S Mugridge, Jeff Coller, John D Gross

Nat Struct Mol Biol. 2018 Dec;25(12):1077-1085.

PMID: 30518847

Abstract:

5'-3' RNA decay pathways are critical for quality control and regulation of gene expression. Structural and biochemical studies have provided insights into the key nucleases that carry out deadenylation, decapping, and exonucleolysis during 5'-3' decay, but detailed understanding of how these activities are coordinated is only beginning to emerge. Here we review recent mechanistic insights into the control of 5'-3' RNA decay, including coupling between translation and decay, coordination between the complexes and activities that process 5' and 3' RNA termini, conformational control of enzymatic activity, liquid phase separation, and RNA modifications.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP10397521	3,3′,5,5′-Tetracarboxydiphenylmethane		10397-52-1	Price

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