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Structural Characterization of Prazosin Hydrochloride and Prazosin Free Base

Vladimir V Chernyshev, Peter W Stephens, Alexandr V Yatsenko, Olga B Ryabova, Vadim A Makarov

J Pharm Sci. 2004 Dec;93(12):3090-5.

PMID: 15514987

Abstract:

The three-dimensional solid-state structures of prazosin hydrochloride, C19H22N5O4+.Cl- (A), and prazosin free base, C19H21N5O4 (B), have been determined by synchrotron X-ray powder diffraction. A and B crystallize in triclinic P-1 and monoclinic Cc space groups, respectively, with one structural unit per asymmetric part. In A and B, the prazosin molecule adopts different conformations, which do not correspond to those obtained by DFT optimizations of protonated and free prazosin.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP19237844-A Prazosin hydrochloride Prazosin hydrochloride 19237-84-4 Price
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