Home
Resources
Publications
Structural Conservation in Prokaryotic and Eukaryotic Potassium Channels

Structural Conservation in Prokaryotic and Eukaryotic Potassium Channels

R MacKinnon, S L Cohen, A Kuo, A Lee, B T Chait

Science. 1998 Apr 3;280(5360):106-9.

PMID: 9525854

Abstract:

Toxins from scorpion venom interact with potassium channels. Resin-attached, mutant K+ channels from Streptomyces lividans were used to screen venom from Leiurus quinquestriatus hebraeus, and the toxins that interacted with the channel were rapidly identified by mass spectrometry. One of the toxins, agitoxin2, was further studied by mutagenesis and radioligand binding. The results show that a prokaryotic K+ channel has the same pore structure as eukaryotic K+ channels. This structural conservation, through application of techniques presented here, offers a new approach for K+ channel pharmacology.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR4242664	Charybdotoxin, recombinant from Leiurus quinquestriatus hebraeus			Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: