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Structural Insight Into the Interaction of ADP-ribose With the PARP WWE Domains

Structural Insight Into the Interaction of ADP-ribose With the PARP WWE Domains

Fahu He, Kengo Tsuda, Mari Takahashi, Kanako Kuwasako, Takaho Terada, Mikako Shirouzu, Satoru Watanabe, Takanori Kigawa, Naohiro Kobayashi, Peter Güntert, Shigeyuki Yokoyama, Yutaka Muto

FEBS Lett. 2012 Nov 2;586(21):3858-64.

PMID: 23010590

Abstract:

The WWE domain is often identified in proteins associated with ubiquitination or poly-ADP-ribosylation. Structural information about WWE domains has been obtained for the ubiquitination-related proteins, such as Deltex and RNF146, but not yet for the poly-ADP-ribose polymerases (PARPs). Here we determined the solution structures of the WWE domains from PARP11 and PARP14, and compared them with that of the RNF146 WWE domain. NMR perturbation experiments revealed the specific differences in their ADP-ribose recognition modes that correlated with their individual biological activities. The present structural information sheds light on the ADP-ribose recognition modes by the PARP WWE domains.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42413026	PARP11 Active human			Price

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