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Structural Relation of Two S-100 Proteins in Bovine Brain; Subunit Composition of S-100a Protein

Structural Relation of Two S-100 Proteins in Bovine Brain; Subunit Composition of S-100a Protein

T Isobe, N Ishioka, T Okuyama

Eur J Biochem. 1981 Apr;115(3):469-74.

PMID: 7238514

Abstract:

Dodecyl sulfate/urea/polyacrylamide gel electrophoresis of S-100a protein, one of the two major components of the brain-specific S-100 protein, indicated the presence of two different subunits in the protein. These subunits (alpha and beta subunits) were purified from the aminoethylated protein by column chromatography on Sephadex G-75, and the purified subunits were subjected to analyses. The results have shown that S-100a protein is a dimer of alpha and beta subunits, with each subunit having a molecular weight of approximately 10500. Structural comparison of these subunits with the subunit of S-100b protein, the other component of S-100 protein consisting of two identical subunits with known amino acid sequence, has revealed that the beta subunit and the subunit of S-100b protein are identical, so that S-100a protein is related to S-100b protein by sharing one of the subunits as a common structural constituent.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR4248909	S-100B Protein from bovine brain			Price

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